Two women walk next to graves of people who passed away due to the coronavirus disease (COVID-19) at the Parque Taruma cemetery in Manaus, Brazil May 20, 2021.Bruno Kelly | ReutersMore than 5 million people have died from Covid-19 in less than two years, as the world continues to battle the highly infectious delta strain of the virus and watches for new mutations.There have been 5,000,425 Covid-19 related deaths recorded across the globe, according to Johns Hopkins University data early Monday. In the U.S., 745,836 people have died due to Covid-19, making it the country with the highest number of recorded deaths.The coronavirus pandemic, which first emerged in China in late 2019, continues to take a deadly toll across the world.It comes as many countries lift pandemic restrictions and end lockdowns that were imposed, to varying degrees, throughout 2020 in a bid to stop the spread of the virus.The rapid development of Covid vaccines, which are clinically proven to greatly reduce severe infection, hospitalization and death from the coronavirus, has helped to dramatically reduce the number of people dying from Covid, particularly in Western nations where the vaccination programs are at an advanced stage.Read more: The delta variant has a mutation that’s worrying experts: Here’s what we know so farNonetheless, there have been increasing concerns in recent months about a rise in infections, hospitalizations and deaths as winter approaches not only among the unvaccinated, who are far more at risk of serious complications from Covid, but also among the elderly (who were among the first to be vaccinated) as vaccine immunity wanes over time.Cases and deaths rising, slowlyThe total number of Covid cases and deaths are increasing around the world, albeit at a slower pace than in previous periods in the pandemic.During the week of Oct. 18-24, the World Health Organization said the number of weekly Covid cases and deaths had increased slightly from the previous week, with over 2.9 million new cases and more than 49,000 new deaths, a 4% and 5% increase respectively.Europe accounted for more than half (57%) of global new weekly cases and was the only region that reported a higher number of cases than in the previous week.Other regions reported declines in the number of new cases compared to the week before. The largest decrease in new cases was reported from the African Region (21%), followed by the Western Pacific Region (17%).The highest numbers of new cases were reported in the U.S. (with 512,956 new cases, although this represented a 12% decrease from the previous week), the U.K. (which reported 330,465 new cases; a 16% increase) and Russia, which reported 248,956 new cases; a 15% increase from the previous week.Delta plusThe Covid-19 virus has gone through several significant mutations that have caused it to spread faster, sparking new waves of infections in the U.S., Europe and Asia.Two mutations, now named the alpha and delta variants, have gone on to be dominant globally. A new mutation of the delta variant is currently being assessed to see if it could make the virus even more infectious.Read more: UK doctors call for urgent return of Covid restrictions as experts monitor new mutationThis so-called “delta plus” variant is being reported in an increasing number of countries, including the U.S., U.K. and Australia.Last week, the WHO said it was closely tracking the delta subvariant, known formally AY.4.2, and that it had been reported in 42 countries so far.”An increase in AY.4.2 sequence submissions has been observed since July,” the World Health Organization said in its last weekly epidemiological update. The majority of cases stemming from the AY.4.2 variant have been detected in the U.K., and these are increasing in frequency, it said.”A gradual increase in the proportional contribution of AY.4.2 has been observed [in the U.K.]; accounting for an estimated 5.9% of overall Delta cases reported in the week beginning 3 October 2021,” the WHO said.Read more: The UK has one of the highest Covid infection rates in the world right now: Here’s whyIt said epidemiological and laboratory studies are ongoing to assess if AY.4.2 makes the virus more transmissible or make antibodies against the virus less effective.